Inhalation Toxicology

PSL offers many years of experience in inhalation toxicology.    Over the years we have conducted numerous study designs via nose-only and whole body exposure routes.  At our site, we have the capability to run studies up to 90-days in length.  For longer term studies, we have a strong partnership with another leading laboratory.  

Exposure Chambers 

• Nose-only
  • Multiple flow-through chambers that are adaptable to specific study designs
• Whole body
  • Multiple chambers ranging in size from 100 liters to 150 liters 

Material Preparation 

• Capable of ball milling a substance in an inert atmosphere
• Numerous sieves for processing
• Various mills that each use a unique form of milling
• Jet-mill that can grind a substance using particle collision 

Aerosol Generation Equipment 

• Adaptable nebulizer setups that can be modified to your specific test substance
• Collision nebulizer that is capable of delivering low chamber concentrations
• Modified Wright Dust Feeder that is capable of delivering high concentrations of dusts
• Wright Dust Feeder for delivery of powders as a dust
• Jet-mill for grinding and delivery of dusts 

Aerosol Concentration Determination 

• Gravimetric determination using a variety of filters and collection media (e.g., sorbent tubes)
• Chemical analysis is performed by our Analytical Chemistry department in a GLP lab
  • A wide selection of instrumentation is available to accomodate formulations of every type
  • Collection devices ranging from simple filters and sorbent tubes to gas impingers with collection solvents to optimize measurements for your specific test substance
• DustTrak™ is used for real-time monitoring of low concentration materials