Genetic Toxicology

PSL provides the full range of GLP genetic toxicology studies, conducted in accordance with GLP standards and regulatory guidelines (FDA, EPA, OECD, ICH).  Studies are regularly conducted on pharmaceuticals, chemicals, dietary ingredients and pesticides. Based upon many years of experience, we can advise you on the most suitable protocols to meet your regulatory needs. 

Gene Mutation

• Bacterial Mutation - Ames Mutagenicity (OECD 471)
• Mammalian Mutation Assay: Mouse Lymphoma Assay (OECD 476)

Chromosome Damage

• In Vitro Cytogenics

  • Micronucleus Assay (Chinese Hamster Cell) (OECD 487)
  • Micronucleus Assay (Human Lymphocyte) (OECD 487)
  • Chromosome Aberration Test (Chinese Hamster Cells) (OECD 473)
  • Chromosome Aberration Test (Human Lymphocytes) (OECD 473)
  • Unscheduled DNA Synthesis (UDS) Test (Mammalian Liver Cells) (OECD 482)
    

• In Vivo Cytogenics

  • Micronucleus Assay (Peripheral Blood) (Rat or Mouse) (OECD 474)
  • Micronucleus Assay (Bone Marrow) (Rat or Mouse) (OECD 474)
  • Chromosome Aberration Test (Mammalian Bone Marrow) (OECD 475)
  • Unscheduled DNA Synthesis (UDS) Test (Mammalian Liver Cells) (OECD 486)

Additional Tests

• Mouse Spot Study (In Vivo) (OECD 484)
• Rodent Dominant Lethal Study (In Vivo) (OECD 478) 
• Mammalian Germ Cell Cytogenetics (In Vivo) (OECD 488)
• Mouse Heritable Translocation (In Vivo) (OECD 485)
• Comet Assay (OECD 489)
• Pig-a Assay

Customized non-GLP screening assays are available upon request.

Let one of the experts at Product Safety Labs help you design a genetic toxicology study.