Study Cancellation, Termination, and Delay Fees

Applicability of Fees - Upon acceptance of a Proposal authorizing PSL to proceed with a study, PSL immediately begins allocating resources, including but not limited to protocol preparation, test material assessment, dedication of technical staff and facilities, review of prior studies, and ordering necessary supplies or test subjects. Due to these commitments, cancellation, termination, or postponement of a study after authorization may result in additional fees. PSL reserves the right to apply cancellation, termination, and delay fees to any study at its discretion. Unless otherwise stated in the Proposal, these fees shall apply to repeat dose toxicology studies and any other studies requiring significant resource allocation or advance procurement of materials or test subjects.

Cancellation Fees – A study is considered canceled if the Client withdraws authorization before initiation (before the protocol is signed by the Study Director). A study canceled after authorization but before initiation is subject to a fee of 5% of the study value

Termination Fees - A study is considered terminated if the Client stops the study after initiation (protocol signed by the Study Director). The following fees shall apply:.

• Terminated before in-life phase begins and before test subject order can be canceled: 20% of study value.
• Terminated before in-life phase begins but after the test subject order cannot be canceled: 40% of study value.
• Terminated after in-life phase begins:
• Study duration less than 90 days: 85% of study value.
• Study duration 90 days or greater:
• Less than 50% of study completed: 75% of study value.
• More than 50% of study completed: 85% of study value.
• After in-life phase is completed: 95% of study value

Delay Fee - A study is considered delayed if the Client postpones the agreed start date after PSL has provided written notice of the proposed initiation date. The following fees shall apply based on the timing of the delay:

• More than 5 weeks before test subject receipt: 0% of study value or expenses incurred.
• 15 to 34 days before test subject receipt: 5% of study value or expenses incurred.
• 14 to 28 days before test subject receipt: 10% of study value or expenses incurred.
• 8 to 13 days before test subject receipt: 20% of study value or expenses incurred.
• 4 to 7 days before test subject receipt: 25% of study value or expenses incurred.
• 3 days or less before test subject receipt: 40% of study value or expenses incurred.